Red I ran aluminum fuel line along the driverside frame rail, and used rubber clamps about every foot to keep it from moving around, then a flexible rubber fuel line to the mechanical fuel pump, on one end, and a flexible line to the fuel cell under the bed. For the pressure issues for my Edelbrock 750cfm, I went with what the carb was rated for, which was also what the stock mechanical fuel pumps are for my engine. It just eliminated a lot of issues and seemed the cheapest solution at the time. Down the line I will convert to braided stainless lines instead of rubber, but for now rubber will do.
If you start using AN fittings prepare to learn a new language and get frustrating figuring out all the fittings you need. It will work great and look great when your done, but is a bit of an expense and learning curve if you haven't used them before.
I also like what Don said about using a flex hose when going through frame members or places abrasion could occur. It reminded me to do the same where my line goes through the under cab brake mount on the frame of my 48 F1.