a few questions

Exactly what number holley carb do you have?
Is it new or has it been rebuilt or altered?
are you running an aircleaner?

What is you timing set at and is you timing marks/cam/tdc all checked and proven????

Does your throttle blades have holes drilled in them?

How far open are the throttle blades front and secondary???

Why are you trying to run so much fuel pressure?

What type float bowls and floats are on your carb???