If the engine has never been fired, your first concern should be the initial run in. With a flat tappet cam this is a period of 20 minutes at 2000 RPM. This requires that you have plenty of air flow to the radiator (BIG fan in front of it), the timing is set to spec and the cooling system is filled and "burped". I do all of mine with an oil pressure and water temp gauge either under the hood where I can watch them, or someone sitting in the car to watch them. This initial run in is THE single most important time in determining how long your camshaft is going to last!!!! Anyway, after the 20 minute run-in I change the oil and filter to eliminate any contaminants left in the engine during the assembly or storage process. After this I will run the engine at varying speeds for the first 500 miles avoiding lugging or over revving the engine, then change the oil and filter again. The rings should be seated by now and it should be ok to just drive the car normally. I run synthetic oil in all my own cars, but I don't switch a fresh engine in a street car over to it til the engine has 3,000 miles on it.....