I mainly stick to the technical high ground. So if I may offer the following;

“Loose”

1. Not fastened, restrained, or contained: loose bricks.
2. Not taut, fixed, or rigid: a loose anchor line; a loose chair leg.
3. Free from confinement or imprisonment; unfettered: criminals loose in the neighborhood; dogs that are loose on the streets.
4. Not tight-fitting or tightly fitted: loose shoes.
5. Not bound, bundled, stapled, or gathered together: loose papers.
6. Not compact or dense in arrangement or structure: loose gravel.
7. Lacking a sense of restraint or responsibility; idle: loose talk.
8. Not formal; relaxed: a loose atmosphere at the club.
9. Lacking conventional moral restraint in sexual behavior.
10. Not literal or exact: a loose translation.
11. Characterized by a free movement of fluids in the body: a loose cough; loose bowels.

“Lose”

1.
a. To be deprived of (something one has had): lost her art collection in the fire; lost her job.
b. To be left alone or desolate because of the death of: lost his wife.
c. To be unable to keep alive: a doctor who has lost very few patients.
d. To let (oneself) become unable to find the way.
e. To remove (oneself), as from everyday reality into a fantasy world.
f. To elude or outdistance: lost their pursuers.
g. To be outdistanced by: chased the thieves but lost them.
2. To be unable to keep control or allegiance of: lost his temper at the meeting; is losing supporters by changing his mind.
3. To fail to win; fail in: lost the game; lost the court case.
4. To fail to use or take advantage of: Don't lose a chance to improve your position.
5. To fail to hear, see, or understand: We lost the plane in the fog. I lost her when she started speaking about thermodynamics.



Kitz