What do you mean, work in these engines? As in high RPM, no, not really. In lower to mid rpm, probably up to 6K, there are lots of guys running oval ports on drag cars. What are you going to be using this car for? You certainly dont need high rpms with a big block stroker....my 505 has all the torque anyone can possibly use. If they are true large oval ports, they will work fine on your engine.