I run mutiple grounds on a loop, a #2ish at the engine block and to a stud welded near the battery, and make a loop with #10 wire. I ground each cylinder head as well and share that ground direct to the ignition.
I do everything possible to get everything at the 'same potential' esp with modern electronics. When i carry a hot wire to a termination i carry its' ground right along with it - just like you'd wire your house.
I use more wire than most, but wire is cheaper than fixing problems in a few years.