I use disposable latex most of the time, and nitrile if I need gloves that are a bit more robust. Neither type will hold up well to paint thinner and other strong solvents, but the nitriles are better in that respect. Aggressive hand cleaners like Lava soap are too hard on my hands, and the gloves have worked very well for me. I would prefer to go thru multiple pairs of disposable gloves than end up with chapped, and dried out, sore hands.