We've got a couple drag cars and one parts truck on E-85. No problems so far, and really like the higher octane and being able to run a bit higher compression. It does scrub off some of your mpg.....

I'd better clarify on the carb, you DO NOT run an alky carb, just a gasoline carb with bigger jets and maybe a bigger shooter... Alky carbs are set for running on Methanol, not E-85....