The short answer is yes.

The longer answer is that the early (51-53 and 54 2bbl) heads have smaller valves and ports and are not really a good head to use on the a larger displacement 354. The early heads also require a different intake as the coolant is circulated thru the intake and the thermostat housing is alsoon the intake. There are no provisions on the end of the heads for the water crossover/thermostat housing like the later Hemis use.