Good question, EG. Without an early Chevy axle here to compare with, I'm not sure. The Econoline may be different in width (wider) and the Chevy may have a bit more drop. The Econoline has more modern brakes, but there are disc brake kits available for early Chevies. I guess you would need to take some measurements to see what the dimensional differences are and then decide if it's worth the trouble. If you take some measurements from your axle I will be happy to measure mine so you can compare them. Econolines used these axles from 1961 through 1967. Chevrolet had similar axles under their vans from 1964 through 1969.