First off, you want to set your timing with the vacuum disconnected. Then depending on the amount of timing advance in the distributor, you go from there, but in any even, you do not want more than 38 degrees total timing at 3000 = rpm. This could mean that at idle it is 16 degrees. You want to be carefull not to have more than 38 degrees at full throttle.

I always hook up my vacuum at the manifold. In this way at light throttle I have plenty of advance for throttle responce and smooth idle but at full throttle I have no vacuum advance, just mechanical and in this way I am ensured no predetination.

Hopefully that helps, we'll see what light some others can shed on this topic.