Kind of, sort of, in theory, and some experts say.....

The 'plenum volume' should not exeed the displacement of the engine.

Take that for what it's worth.......
A lot of guys running 3, 4, 6 carbs have some of them blocked off for driveability.

Invest in a Uni-Syn carb synchronizer (Edelbrock sells them).

Hope the info helps....
Jeff