41 chevy coupe & S10 frame

I have a friend of mine who has a real nice 41 chevy coupe body, but no chassis. He wants to know how much of a problem it would be to use an S10 complete chassis. Im sure some of you out there have used this setup. Please let me know what it takes to use this combo, and does he need the chassis from a 2 wheel drive or 4 wheel drive. He is a professional welder so he has no problem with making the frame longer if needed, and making it wider if need be. Im always reading on different forums of people using the S10 on older chevys. Thanks for any feedback on this.

look at a mid 70 into the 80's mid GM size cars, you will have to redo the kick out on the side of the frame BUT ya wont have to worry about the kick-UP of the frame in the rear.
BUT if he just has to use a S10 frame ya want a 2wheel drive one, OR the front frame section from a 2000 or newer 2wheeldrive Blazer that way you can upgrade the front rotors to a much larger size if ya want to by using late model Camaro (like a 2000 model) hubs & rotors.