Welcome aboard Brad.

"CAN" is a great term. "SHOULD" is another. You can put anything on anything if you have the determination and the skill. I would question whether an S-10 is really wide enough to work out correctly.

I assume you are trying to get coil spring suspension to replace the leaves, and discs to replace the drums. The S-10 probably appeals because it's perceived to be "inexpensive" to achieve both goals. If all you look at is initial cost of pieces of hardware that assumption would appear true. However, doing a front clip change is not a job for an amateur unless he is very talented and patient enough to do homework on how to do it right. Taking someone elses word for it (e.g. the S-10 swap) is not a good thing to do. Good that you've asked around before jumping in. I would suggest you spend this season looking at actual installations other F100 guys have done to achieve the same goals you desire. Discuss with them the pros and cons, if they're happy with their choice, and if they'd do it the same way again.

Changing the front chassis clip also entails re-engineering the mounting points for the whole front sheetmetal assembly. This is a primary reason why some of the more experienced folks will choose a route that retains the original rails and then attaches other, later model components. There are kits to install Mustang II, Cordoba, Volare, and Dakota suspensions under these frames. If you check the Truckin' magazines you'll likely find lot's of ads that represent these suppliers.

Remember, it might be cheaper to buy a donor clip initially, but if it's installation ruins the truck, it becomes VERY expensive (not to mention disheartening).