With enough "massaging" anything can fit in / on anything... IMHO, the use of a S-10 frame as a foundation for the coupe will be a mistake. You'll devalue the body and the re-sale will be nil.

I'm of the opinion that an original frame or reproduction would put you miles ahead (pun intended!) in ease of body installation and fitment and help hold the value(s) you'll be looking for in the future.

Suspensions front and rear will need to be worked on in either case ( S-10 or OEM) so you won't really save time and money there...

Again, just my opinion.. it's your car / project, let us know what you decide.