The S-10 frame or better yet the Blazer frame , which is boxer & does not have the kick-up behind the cab will work in certain applications. The early fords are not amoung them.

One of the application I am thinking of is the 47-54 Chevy/GMC 1/2 ton.

Having said that they hardly never look just right because of their narrow front track.

There is even a outfit that makes a kit for this application.