I used lacquer and enamel primers for the first 25 years I painted, and they both can cause serious problems.

Urethane primer offers so many advantages, I won't use anything else. I have not had a single failure since switching to it about 15 years ago, and I work seven days a week! It doesn't shrink, allow moisture in, the adhesion is great, and I don't even use a sealer, unless I need a different color under the base, or if I bodywork on top of the primer. I can't even think of any way it could be improved! No, it doesn't sand as easy, but I use 360 with no problems, and it goes fairly quickly.