In 1962 I drove a stock 40 Ford 2 dr sedan from Camp Pendleton, Ca. to Dayton, Ohio on leave from the Marine Corps. It was all Route 66 until Illinois where bits and pieces of Interstate 70 were open and I almost got blown off the road by an 18 wheeler who was in some kind of a hurry. I wouldn't want to do it today with the same car as it was then, absolutely too dangerous.
Two years later I drove a sbc powered 36 Ford 5 window coupe from Dayton to Camp Pendleton, much more enjoyable trip and even though it was all old school I wouldn't hesitate to do it again if I still had the car.
Your car do as you wish, but I doubt you will drive it very long bone stock.

