Whats up all?

What do you guys look for when you tune engines? I have experience in tuning small engines and small stuff like that but what about the big boys? I know the parts of the big carbs i.e. acclerator pump, main and idle circuts, ummm, air bleed valves, holley power valves, fuel bowles and all thats in them, lol thats all i can think of now . i assume its pratice and the good ol eyes and ears and nose right?

Enlighten me please,
-CJP