You can kill some of, if not all of the detonation problems with a slightly too high of a CR by selecting a cam with a late intake close.

This bleeds off some of the compression so you can run the engine without detonation problems.

If you can't find a cam with a late intake close, a cam that's the next step more radical will do the same thing.

We did the reverse in my bother-in-law's 413 cross-ram Dodge quite a few years back.
The car ran great, but we got into the gotta have more HP bit, stuck in a more radical cam with symettrical timing and ended up with detonation both at light, low rpm throttle settings and full-on blasts.
Then we found out ChryCo's factory cams had the late close so as to avoid detonation problems.

Even with the better and higher octane gasoline from times past.

With today's low octane gasoline and low comp engines - far as carbureted, non-computerized engines go anyway, a mild cam will make better HP than will a radical one.

I do miss the rumpity-rumpity sounds though....