That combo should get you there. A few years ago (well, more than a few), I built a 400 Poncho motor in a 3506# GTO. Used a 312/320 split overlap with nominal .544 lift (on 1.6 rockers, Crane, I think), 11.8:1 compression, balanced, single plane manifold with 850 double pumper on CAM-2, Muncie wide-ratio, Hayes steel clutch & flywheel, 4:10 gears, MT wrinklewalls and those weird Lakewood No-Hop traction bars. Pulled some low mid to low 11's at Cornhusker dragway way back when I lived in Nebraska. Launched at 6500, shifted at 7000. Never broke a thing. It had the potential to go faster- but I would have had to go to 4.88's or 5.10's.

You could go lower on the compression and depend on the anaesthetic to get you there.

Stay away from the bluff, though. The deceleration lane is a bitch.